Fertility Turkey – IVF in Turkey

Round Spermatid Injection (ROSI)

The female reproductive system and organs have a complex structure and vital importance. For this reason, gynecological consultations and examinations are needed at regular intervals to evaluate reproductive health. Regardless of whether there are complaints or not, it is recommended to have a gynecology examination at least once a year. With regular gynecological examinations, problems in the reproductive system can be diagnosed early and further development of the problem can be prevented. It is better to prevent the disease than to cure it later.

What is the New Generation of ROSI?

In February 2019, the we announced its first ROSI pregnancy. This situation was actually only the visible part of the iceberg. Because Prof. Dr. Recai Pabuçcu and his team had gone to Dr. Tanaka and his team from Japan where the foundations of the ROSI technique were laid and which had the largest ROSI series in the world. The team arrived in Turkey at the end of this education process and has achieved the first pregnancy in Turkey with their modern ROSI technique. In summary, the ROSI technique in the modern sense will be the glimmer of hope for thousands of families.

What we call azoospermia is having semen in man but there is no live sperm cells in the semen. One percent of men have azoospermia in population and thirty percent of men consulting for infertility have azoospermia, too.

What is ROSI technique? What is the difference from a classic IVF?

Before we talk about the ROSI technique, we must understand the stages of sperm production. Sperm production is a complex process that takes about 90 days. In this process;

  • Spermatogonium (most precursor cell)
  • Spermatocytes (precursor cells)
  • Spermatid (premise)
  • Spermatozoa (mature) cells enter the maturation process respectively.

Among these cells which we mentioned above, mature cell is the best fertilization capacity. However, since these cells are not present in azoospermia men, mature sperm cells are examined in the tissues taken from the testis. Testicular biopsy is called TESE. In the TESE procedure, up to 60% of men have mature sperm, but for men that cannot be found, the process can be a bit problematic. In this case, if there are no mature cells, the precursors are investigated and especially the spermatid precursors have a round or elonge sperm cell. Under normal conditions, these precursor cells are not capable of fertilizing the egg. However with ROSI technique, this premise makes it possible for round and elongated spermatids to fertilize the egg. Special technologies and techniques are used for this process.

In classical IVF technique, mature sperm cells are collected from the ejected semen sample, the best is selected and given into the egg. In the ROSI method, since there are no mature sperm cells in the semen, the procedure cannot be performed. The round cells extracted from the tissue obtained by TESE are introduced into the oocyte.

We have been implementing this process since February 2019.Equipment is being used from Japan.

The New Generation of ROSI-Summary in 7 steps:

  1. Assessment of the situation of man and woman.
  2. Asking hormone analysis to man and treatment with 6-8 weeks according to situation.
  3. When the treatment is over for man, start of egg augmentation on the 2nd or 3rd day of menstruation for spouse.
  4. Collection of mature eggs and the searching of sperm cells by biopsy from the testes called TESE at the same time
  5. If there are mature sperm cells with mature cells or premature fertilization of the egg with round or long sperm cells.
  6. Stimulation of the eggs to be fertilized by special electrical activation.
  7. Transfer of obtained embryos.

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